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A B C D E F G H I J K L M N O P Q

Test Identifier Information

 
Registration CodeDJCV
Method

Polyoma virus DNA detection and subsequent differentiation between BK and JC virus.

External Price$225.51(Exclusive of GST)
  

Specimen Collection

 
Specimen Collection Protocols

Specimen type for Polyoma Virus PCR©

 

Specimen:

 

JC Virus

CSF at least 0.5 mL in a sterile container.

 

BK Virus

5 mL EDTA blood


Urine samples are no longer routinely accepted for testing for BK or JC virus on immunosuppressed patients. Urine should only be sent for JC or BK virus testing after consultation with the laboratory.

 

Testing is currently being performed in Auckland Hospital Laboratory.

Patient SpecimenSee specimen collection protocol
Paediatric SpecimenNA
  

CHLabs Laboratory

 
DepartmentMicrobiology-Virology
Contact Details** Unknown email address **
Contact Phone Number03-3640416 / ext. 80416
Test AvailabilitySent to LabPlus, Auckland
Turnaround Time1 - 2 wks
Interpretation

Interpretation:

Detection of virus does not always correspond to clinically important disease.

In immunocompromised individuals BK DNA can be detected in the absence of disease, therefore results should be interpreted in conjunction with clinical findings.

Due to the sensitivity of some JC PCR assays a positive test for JC supports diagnosis, but a negative result does not exclude it. Repeating the PCR on a specimen obtained later in the course of disease may assist with diagnosis in some patients in whom the initial PCR is negative.

Additional Information

Sent to LabPlus. The following information is referenced to the ADHB LabPlus Laboratory Handbook:

 

JC virus

JC virus infection is usually acquired in childhood or early adolescence with seroconversion rates rising from approximately 90% in young adults to almost 100% in the elderly. Primary infection in healthy subjects is essentially asymptomatic with virus persisting thereafter in the kidneys, CNS (brain) and peripheral white blood cells. Reactivation and shedding of virus can occur in the urine of pregnant women and organ transplant recipients without clinical sequelae. In patients with depressed cell mediated immunity including AIDS and transplantation, reactivation can occasionally result in severe, usually fatal, central nervous system disease (PML).

 

BK virus

BK virus is usually acquired in early childhood with seroconversion rates rising to nearly 100% by the age of 10-11 years. Primary infection in healthy subjects is essentially asymptomatic with the virus persisting thereafter in the kidneys and peripheral white blood cells. Reactivation of the virus with shedding in the urine occurs frequently in the immunosuppressed and has a low predictive value for BK virus disease. BK viraemia is a better correlate of BK virus nephropathy in renal transplant recipients and is probably also a better predictor of BK disease in haematopoietic stem cell transplant patients.

Delphic Number Test Number2881

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