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Test Identifier Information

 
Registration CodeB701
Method

 

This assay uses primers specific for HLA-B*57, HLA-B*57:01 as well as HGH (used as an internal control of DNA quality and amplification success) to amplify via PCR, and assess product presence on an agarose gel.

 

Diagnostic Use / Indications

Hypersensitivity to abacavir (an anti-retroviral drug) affects about 4% of patients who receive the drug for HIV-1 infection.

Abacavir hypersensitivity is an immune-mediated reaction that typically occurs within the first 6 weeks of therapy. Signs and symptoms of abacavir hypersensitivity are nonspecific, which makes the diagnosis challenging, but can present with any of the following symptoms: Fever, Rash, GI, malaise or respiratory. Continuation on abacavir after hypersensitivity presents can be fatal.

Susceptibility to a clinically significant hypersensitivity syndrome associated with abacavir use seems to have a strong genetic component where the presence of HL-B*5701 is strongly predicitive of hypersensitivity.

External Price$139.28(Exclusive of GST)
  

Specimen Collection

 
Specimen Collection Protocols

Send to the laboratory within 24 hours

Patient Specimen4.0mL EDTA(Lavender)
Paediatric Specimen0.5 mL - 1 mL EDTA blood
Sample Delivery to LabSend to the laboratory within 24 hours
  

CHLabs Laboratory

 
DepartmentBiochemistry - Molecular Pathology
Contact Details Email Email
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Contact Phone Number03 3640 548
Test Availability9am to 5pm, Monday to Friday
Turnaround TimeWithin 4 weeks
Reference Interval

Detected

Not detected

Additional Information

HLA B5701

Delphic Number Test Number6419

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