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A B C D E F G H I J K L M N O P Q

Test Identifier Information

 
Registration CodeVREP
Diagnostic Use / Indications

Diagnostic Use and Interpretation

 

Human herpes virus 8 (HHV8) or Kaposi?s sarcoma associated herpes virus (KSHV) is a member of the gamma-herpes virus subfamily. HHV8 is distributed worldwide with five distinct subtypes (A to E). Seroprevalence of HHV8 varies widely, being highest in Africa and Mediterranean regions and relatively low in western countries. HHV8 is regarded as the causative agent of Kaposi?s sarcoma and it is also found in a small group of lymphoproliferative disorders namely primary effusion lymphoma, (PEL) multicentric Castleman?s disease (MCD) and MCD- associated plasmablastic lymphoma.

Infection with HHV8 is generally without consequence in immunocompetent hosts. In patients who are immunodeficient either through infection (HIV) or transplant associated immunosuppression, HHV8 may reactivate and cause lymhoproliferative disease. Kaposi?s sarcoma (KS) occurs in 0.5 %- 5% of organ transplant recipients, depending on the patient?s geographic origin and the immunosuppressive regimen used .

Assessment of HHV8 viral load in WBC and plasma provides a useful tool for detection of HHV8 reactivation and therefore risk of HHV8 disease and for monitoring response to intervention.

Information from Labplus

External Price$0.00(Exclusive of GST)
  

Specimen Collection

 
Pre-Testing Requirements

Contact  laboratory for price.

Specimen Collection Protocols

 

Other samples - Biopsy of Kaposi's sarcoma. Fresh tissue in sterile disposable plastic container. Send chilled on ice. Fresh or frozen tissue gives the best results, but fixed or embedded tissue can be used if a fresh sample is not available.
 

Bone marrow.

Testing and information from Labplus

Patient Specimen5mL EDTA(Lavender) (always required)
Paediatric Specimen0.5mL EDTA(Lavender) (always required)
  

CHLabs Laboratory

 
DepartmentMicrobiology-Virology
Contact Details** Unknown email address **
Contact Phone Number03-3640416 / ext. 80416
Test AvailabilityAfter consultation with Microbiologist
Turnaround Time2 weeks
Referred to Labplus
Additional Information

Diagnostic Use and Interpretation

 

Human herpes virus 8 (HHV8) or Kaposi?s sarcoma associated herpes virus (KSHV) is a member of the gamma-herpes virus subfamily. HHV8 is distributed worldwide with five distinct subtypes (A to E). Seroprevalence of HHV8 varies widely, being highest in Africa and Mediterranean regions and relatively low in western countries. HHV8 is regarded as the causative agent of Kaposi?s sarcoma and it is also found in a small group of lymphoproliferative disorders namely primary effusion lymphoma, (PEL) multicentric Castleman?s disease (MCD) and MCD- associated plasmablastic lymphoma.

Infection with HHV8 is generally without consequence in immunocompetent hosts. In patients who are immunodeficient either through infection (HIV) or transplant associated immunosuppression, HHV8 may reactivate and cause lymhoproliferative disease. Kaposi?s sarcoma (KS) occurs in 0.5 %- 5% of organ transplant recipients, depending on the patient?s geographic origin and the immunosuppressive regimen used .

Assessment of HHV8 viral load in WBC and plasma provides a useful tool for detection of HHV8 reactivation and therefore risk of HHV8 disease and for monitoring response to intervention.

 

Delphic Number Test NumberVREP

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