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A B C D E F G H I J K L M N O P Q

Test Identifier Information

 
Registration CodeHMCR
Method

ELISA

External Price$63.88(Exclusive of GST)
  

Specimen Collection

 
Patient Specimen4.0mL Red Top,
Paediatric Specimen0.5mL
Sample Delivery to LabRoom temperature
  

Instructions for Referral to CHLabs

 
Aliquot Instructions200uL serum (minimum) 1 mL serum (preferred)
Aliquot Transport to CHLRoom temperature
  

CHLabs Laboratory

 
DepartmentBiochemistry - Immunology
Contact Details Email Email
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Contact Phone Number(03) 364 0414 | x80414
Turnaround Time4 weeks
Reference Interval

Results (AU/L)

  • Negative: ≤3
  • Weak positive: 4 - 10
  • Positive: 11 - 20
  • Strong positive: >21 
Interpretation

Values >4 indicate presence of antibodies to 3-Hydroxy-3-Methylglutaryl CoEnzyme A Reductase (HMGCR) and suggest autoimmune myopathy. 

IgG antibodies to HMGCR in the setting of muscle weakness and a raised CK are highly suggestive of an autoimmune necrotising myositis.  Many cases are associated with statin exposure although this is not universal.  In those with statin exposure the myositis does not resolve with drug cessation.

Mammen AL, Chung T el al.:Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Arthritis Rheum. 2011 Mar;63(3):713-21. 
Additional Information

HMGCR is performed as part of the myositis panel of tests offered by CHL


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